Charles C. Hong, M.D., Ph.D., F.A.H.A

Charles C. Hong
  • Chair of Medicine
  • Professor
  • Department of Medicine
  • Division of Cardiology
  • Academic Address: Clinical Ctr - Tower B 788 Service Rd Room B425 East Lansing MI 48824
  • Academic: 517-432-8652

Academic Support Staff: Christina Buccerri



Charles (Chaz) Hong is Chair, Department of Medicine at the MSU College of Human Medicine.

Dr. Hong is honored to lead the MSU CHM Department of Medicine at this transformative period, with exciting opportunities in discovery, innovation, education, and patient care. His vision is to help make MSU a dynamic innovator in Academic Medicine, attracting and developing future leaders who will transform the innovation landscape across Michigan and build a more just and healthy society.

Dr. Hong’s research focuses on bridging chemical biology, cell and molecular biology, stem cell biology, genetics, and cardiology.  His notable scientific contributions include the discovery of the critical role of phosphoinositide 3-kinase (PI3K) in vein formation, which foreshadowed the recognition that aberrant PI3K activation is a common cause of clinical venous malformations. He also discovered the first small molecule inhibitor of bone morphogenetic protein (BMP) signaling, which led to a clinical stage therapeutic program for devastating human diseases. His ongoing investigations include unraveling the significance of centrosome breakdown in postnatal heart maturation and its involvement as a cause of infantile heart failure. Dr. Hong is also pioneering novel therapies targeting of a key pro-oncogenic signaling pathway activated downstream of Warburg Effect.  Dr. Hong edited two books, including the first book focused on chemical biology of stem cell and regenerative medicine. He serves on editorial boards of numerous scientific journals, and is the inaugural Chief Editor of Frontiers in Drug Discovery.  He is an elected member of American Society for Clinical Investigation and a Fellow of American Association for the Advancement of Science.  He is a passionate advocate for medical education, currently serving on the Board of Directors of the Sarnoff Foundation.  His clinical expertise is cardiovascular genetics.

Dr. Hong, a Detroit native, completed his bachelor’s degree at MIT, his MD-PhD and internal medicine residency at Yale School of Medicine, his cardiology fellowship at Massachusetts General Hospital, and his research fellowships in chemical biology at Harvard Medical School.  Dr. Hong joins MSU from University of Maryland School of Medicine, where he served as the Melvin Sharoky Professor of Medicine, and Co-Chief of Cardiovascular Medicine.  Prior to that, he was on faculty at Harvard Medical School and Vanderbilt University School of Medicine. Most importantly, Chaz is a life-long Spartans fan.



1988 B.S. Life Sciences, Massachusetts Institute of Technology
1998 M.D., Yale School of Medicine
1998 Ph.D. with Highest Honors, Genetics, Yale School of Medicine

Post Graduate Education and Training
1998 - 1999 Internship, Yale-New Haven Hospital
1999 - 2001 Residency, Internal Medicine, Yale-New Haven Hospital
2001 - 2004 Fellowship, Cardiology, Massachusetts General Hospital
2001 - 2005 Research Fellowship, Chemical Biology, Harvard Medical School

2001 ABIM Board Certification in Internal Medicine (lapsed)
2005 ABIM Board Certification in Cardiovascular Disease