Selected Publications
Complete list of publications for Jennifer Klomp
Klomp JE, Diehl JN, Klomp JA, Edwards AC, Yang R, Morales AJ, Taylor KE, Drizyte-Miller K, Bryant KL, Schaefer A, Johnson JL, Huntsman EM, Yaren TM, Pierobon M, Baldelli E, Prevatte AW, Barker NK, Herring LE, Petricoin EF 3rd, Graves LM, Cantley LC, Cox AD, Der CJ, Stalnecker CA. Determining the ERK-regulated phosphoproteome driving KRAS mutant cancer. Science. 2024.
PMID: 38843329 DOI: 10.1126/science.adk0850
Klomp JA, Klomp JE, Stalnecker CA, Bryant KL, Edwards AC, Drizyte-Miller K, Hibshman PS, Diehl, JN, Lee YS, Morales AJ, Taylor KE, Peng S, Tran NL, Herring LE, Prevatte AW, Barker NK, Hover LD, Hallin J, Chowdhury S, Coker O, Lee HM, Goodwin CM, Gautam P, Olson P, Christensen JG, Shen JP, Kopetz S, Graves LM, Lim KH, Wang-Gillam A, Wennerberg K, Cox AD, Der CJ. Defining the KRAS- and ERK- dependent transcriptome in KRAS-Mutant Cancers. Science. 2024.
PMID: 38843331 DOI: 10.1126/science.adk0775
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Holderfield M, Lee BJ, Jiang J, Tomlinson A, Seamon K, Mira A, Patrucco E, Goodhart G, Dill,J,Gindin Y, Dinglasan N, Wang Y, Lai LP, Cai S, Jiang L, Nasholm N, Shifrin N, Blaj C, Shah H, Evans J, Montazer N, Lai O, Shi J, Ahler E, Quintana E, Chang S, Salvador A, Marquez A, Cregg, J, Liu Y, Milin A, Chen A, Bar-ziv T, Parsons D, Knox, JE, Klomp JE, Roth J, Rees M, Ronan M, Cuevas-Navarro A, Hu F, Lito P, Santamaria D, Aguirre AJ, Waters AM, Der CJ, Ambrogio C, Wang Z, Gill AL, Koltun, ES, Smith JAM, Wildes D, Singh M. Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature. 2024.
PMID: 38589574 DOI: 10.1038/s41586-024-07205-6
Edwards AC, Stalnecker CA, Morales AJ, Taylor KE, Klomp JE, Klomp JA, Waters AM, Sudhakar
N, Hallin J, Tang TT, Olson P, Post L, Christensen JG, Cox AD, and Der CJ, TEAD inhibition overcomes YAP1/TAZ-driven primary and acquired resistance to KRASG12C Inhibitors. Cancer Res. 2023.
PMID: 37934103 DOI: 10.1158/0008-5472.CAN-23-2994
Lee YS, Klomp JE, Stalnecker CA, Goodwin CM, Gao Y, Droby GN, Vaziri C, Bryant KL, Der CJ,Cox AD. VCP/P97, a Pleiotropic Protein Regulator of the DNA Damage Response and Proteostasis, Is a Potential Therapeutic Target in KRAS-Mutant Pancreatic Cancer. Genes Cancer. 2023.
PMID: 36923647 DOI: 10.18632/genesandcancer.231
Goodwin CM, Waters AM, Klomp JE, Javaid S, Bryant KL, Stalnecker CA, Drizyte-Miller K, Papke B, Yang R, Amparo AM, Ozkan-Dagliyan I, Baldelli E, Calvert V, Pierobon M, Sorrentino JA, Beleen AP, Bublitz N, Luthen M, Wood KC, Petricoin EF 3rd, Sers C, McRee AJ, Cox AD, Der CJ. Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer. Cancer Res. 2023.
PMID: 36346366 DOI: 10.1158/0008-5472.CAN-22-0391
Klomp JE, Le YS, Goodwin CM, Papke B, Klomp JA, Waters AM, Stalnecker CA, DeLiberty JM, Drizyte-Miller K, Yang R, Diehl JN, Yin HH, Pierobon M, Baldelli E, Ryan MB, Li S, Peterson J, Smith AR, Neal JT, McCormick AK, Kuo C, Counter CM, Petricoin EF 3rd, Cox AD, Bryant KL, Der CJ. CHK1 Protects Oncogenic KRAS-expressing Cells from DNA Damage and is a Target for Pancreatic Cancer Treatment. Cell Rep. 2021.
PMID: 34852220 DOI: 10.1016/j.celrep.2021.110060
Diehl JN, Klomp JE, Snare KR, Blake DR, Hibshman PS, Stalnecker CA, Gilbert TSK, Baldelli E, Pierobon M, Herring LE, Papke B, Yang R, Hodge RG, Rashid NU, Petricoin EF 3rd, Graves LM, Cox AD, and Der CJ. Defining the KRAS-regulated Kinome in KRAS-mutant Pancreatic Cancer. J Biol Chem. 2021.
PMID: 34688654 DOI: 10.1016/j.jbc.2021.101335
Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KK, Gilbert TSK, Stalnecker CA, Javaid S, Barkovskaya A, Grover KR, Hibshman PS, Blake DR, Schaefer A, Nowak KM, Klomp JE, Hayes TK, Kassner M, Tang N, Tanaseichuk O, Chen K, Zhou Y, Herring LE, Graves LM, Penn LZ, Yin HH, Aguirre AJ, Hahn WC, Cox AD, and Der CJ. Targeting p130Cas- and Microtubule-dependent MYC Regulation Sensitizes Pancreatic Cancer to ERK MAPK Inhibition. Cell Rep. 2021.
PMID: 34192548 DOI: 10.1016/j.celrep.2021.109291
Klomp JE, Klomp JA, Der CJ. The ERK Mitogen-activated Protein Kinase Signaling Network: the Final Frontier in RAS Signal Transduction. Biochem Soc Trans. 2021.
PMID: 33544118 DOI: 10.1042/BST20200507
Klomp J, Hyun J, Klomp JE, Pajcini K, Rehman J, Malik AB. Comprehensive Transcriptomic Profiling Reveals SOX7 as an Early Regulator of Angiogenesis in Hypoxic Human Endothelial Cells. J Biol Chem. 2020.
PMID: 32071080 DOI: 10.1074/jbc.RA119.011822
Collins KB, Kang H, Matsche J, Klomp JE, Rehman J, Malik AB, Karginov AV. Septin2 Mediates Podosome Maturation and Endothelial Cell Invasion Associated with Angiogenesis. J Cell Biol. 2020.
PMID: 31865373 DOI: 10.1083/jcb.201903023
Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, Ng RWS, Gautam P, Bryant KL, Esposito D, Campbell SL, Petricoin EF 3rd, Simanshu DK, Aguirre AJ, Wolpin BM, Wennerberg K, Rudloff U, Cox AD, Der CJ. Atypical KRASG12R Mutant is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer. Cancer Discov. 2020.
PMID: 31649109 DOI: 10.1158/2159-8290.CD-19-1006
Klomp JE, Shaaya M, Matsche J, Rebiai R, Aaron JS, Collins KB, Huyot V, Gonzalez AM, Muller WA, Chew TL, Malik AB, Karginov AV. Time-variant SRC Kinase Activation Determines Endothelial Permeability Response. Cell Chem Biol. 2019.
PMID: 31130521 DOI: 10.1016/j.chembiol.2019.04.007
Bryant KL, Stalnecker CA, Zeitouni D, Klomp JE, Peng S, Tikunov AP, Gunda V, Pierobon M, Waters AM, George SD, Tomar G, Papke B, Hobbs GA, Yan L, Hayes TK, Diehl JN, Goode GD, Chaika NV, Wang Y, Zhang GF, Witkiewicz AK, Knudsen ES, Petricoin EF 3rd, Singh PK, Macdonald JM, Tran NL, Lyssiotis CA, Ying H, Kimmelman AC, Cox AD, Der CJ. Combination of ERK and Autophagy Inhibition as a Treatment Approach for Pancreatic Cancer. Nat Med. 2019.
PMID: 30833752 DOI: 10.1038/s41591-019-0368-8
Kang H, Hong Z, Zhong M, Klomp J, Bayless KJ, Mehta D, Karginov AV, Hu G, Malik AB. Piezo1 Mediates Angiogenesis through Activation of MT1-MMP Signaling. Am J Physiol Cell Physiol. 2019.
PMID: 30427721 DOI: 10.1152/ajpcell.00346.2018
Klomp JE, Huyot V, Ray AM, Collins KB, Malik AB, Karginov AV. Mimicking Transient Activation of Protein Kinases in Living Cells. Proc Natl Acad Sci U S A. 2016.
PMID: 27956599 DOI: 10.1073/pnas.1609675114
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Zimnicka AM, Husain YS, Shajahan AN, Sverdlov M, Chaga O, Chen Z, Toth PT, Klomp J, Karginov AV, Tiruppathi C, Malik AB, Minshall RD. Src-dependent Phosphorylation of Caveolin-1 Tyr-14 Promotes Swelling and Release of Caveolae. Mol Biol Cell. 2016.
PMID: 27170175 DOI: 10.1091/mbc.E15-11-0756